Introduction: Venous and arterial thrombosis are frequently observed complications in patients with severe novel coronavirus disease 2019 (COVID-19) infection who require hospital admission. In this study, we evaluate the epidemiology of venous and arterial thrombosis events in ambulatory and post- discharged patients with COVID-19 infection. Materials and Method: EMBASE and MEDLINE were searched up to July 21st, 2021, in addition to other sources. We included studies that assessed the epidemiology of venous and arterial thrombosis events in ambulatory and post dischargepost-discharged COVID-19 patients. Results: A total of 16 studies (102,779 patients) were identified. The overall proportion of venous thromboembolic events in all patients, ambulatory and post dischargepost-discharge, was 0.80% (95% confidence interval [CI]: 0.4437 to 1.278), 0.28% (95% CI 0.0703 to 0.640), and 1.16 % (95% CI: 0.694 to 1.7437), respectively. Arterial events occurred in 0.75% (95% CI: 0.274 to 1.471) of all patients, 1.45% (95% CI: 1.103 to 1.864) of post dischargepost-discharge patients, and 0.23% (95% CI: 0.01987 to 0.663) of ambulatory patients. The pooled incidence rate estimates per 1,000 patient-days for VTE events were 0.056 (95%CI 0.030 – 0.082) and 0.124 (0.067 – 0.1986) for outpatients and post-discharge, respectively, whereas for arterial events were 0.103 (95%CI 0 – 0.303) and 0.264 (95% CI 0.162 – 0.3766). Conclusion: This study found a low risk of venous and arterial thrombi in ambulatory and post-discharge COVID-19 patients, with a higher risk in post-discharged patients compared to ambulatory patients. This suggests that regular universal thromboprophylaxis in these patient populations is probably not necessary.