After the brief presentation of the major karstic areas in Morocco, the article focused essentially on the Atlas mountains to investigate the impact of the agriculture on the natural systems equilibrium. Socio-economic changes (demographic pressure, escalation of the landscape use, utilisation of new techniques in water harvesting, etc... ) have sometimes fathered mechanisms of degradation. Many indicators seem to reflect these mechanisms. The pedologic indicators, soil erosion, the hydrologic and geomorphic indicators, are apprehended to demonstrate existent correlation between different variables and the often negative impacts of land over-use in the karstic domain of the Middle Atlas.