Graphical abstractSevere alcoholic hepatitis Decoy receptor sST2 HighlightsThe IL-33/ST2 pathway is defective in the neutrophils of patients with severe alcoholic hepatitis.This defect is associated with a higher risk of developing infection.Dosage of the decoy receptor sST2 helps identify patients at risk of death and/or infection.The defect in IL-33/ST2 in neutrophils is responsible for lower migration capacities.Treating neutrophils with recombinant IL-33 restores, at least in part, their migration capacities.

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