The agricultural sector represents the highest percentage of child laborers in Egypt. Children of poor rural families work in farms to increase a household's income. Aim: To assess knowledge, attitude, and practice of children working in agriculture sector about pesticide hazards. Methodology: Descriptive design was used in this study. The study sample includes 97 preparatory school students performing agricultural work from different educational grade. Tools: Tool (1): Children working in agriculture' structured interview questionnaire. Tool (2): An observational checklist measures child wearing personal protective equipment's (PPEs). Results: All children have inadequate knowledge, negative attitude, poor practice, and poor first aid practice. More than half of children wear protective boots and gloves, but more than three-quarters does not wear glasses or goggles. Conclusion: There was no statistically significant correlation between total scores of knowledge, practice and attitude of the studied group. Recommendations: Organizing workshops and school activities such as drama plays, painting, and games about pesticides and their dangers with each agricultural cycle in schools located in rural areas can be effective.