Objective: Investigating the reliability of mandibular canine maturation stages in predicting pubertal growth spurt in a sample of Egyptian orthodontic patients. Subjects and Methods: A retrospective, cross-sectional study was carried out on the radiographic records (left lateral cephalometric, panoramic, and left hand and wrist x-rays) obtained from 250 patients who were attending private clinics on Delta area, Egypt. The age of the patients ranged from 7 to 18 years. Mandibular canine calcification stages (MCC) were assessed according to Demirjian's method for dental maturity assessment. Skeletal maturity was assessed by the ossification stages of the middle phalanx of the third finger (MP3) using Hagg and Taranger method, and the cervical vertebrae maturation index (CVMI) was evaluated using Hassel and Farman method. Results: Chi-square tests have shown highly significant associations between the mandibular canine calcification stages (MCC) and both CVMI and MP3 maturation stages (p<0.001). MCC stage F had shown a moderate correlation with MP3 FG and CVMI 2 that corresponded to the onset of pubertal growth. Conclusions: MCC stage F can be used for prediction of the onset of pubertal growth, while the prediction of the peak or the post-peak periods using MCC method may be unreliable.