Introduction: Despite the fact that immunization is proven to be the most successful and cost-effective public health intervention in reducing childhood morbidity and mortality, full immunization coverage remains abysmally low in Nigeria, with a concomitant high burden of vaccine preventable diseases (VPDs) among children. This study aimed to assess the knowledge, attitude and compliance with full immunization of children against VPDs among pregnant mothers in Sokoto, Nigeria. Material and Methods: A cross-sectional study was conducted among 220 randomly selected pregnant mothers attending the antenatal care (ANC) clinic of UDUTH, Sokoto, Nigeria. Data were collected with a set of structured, pretested, interviewer-administered questionnaire. Results: The mean age of the respondents was 28.12 + 5.58 years. Most of them were married (91.8%), Muslims (76.8%) and had at least secondary education (79.1%). Whereas less than half of respondents had good knowledge of VPDs (49.1%) and benefits of immunization (44.1%), most of them (91.8%) had good knowledge of the National Immunization Schedule. Although, most of the respondents showed positive attitude towards childhood immunization, only about twothirds (65.5%) had their youngest child fully immunized. The main reasons given by the respondents whose children were never vaccinated were husbands' disapproval (52.6%) and lack of information on the immunization schedule (26.3%). Conclusion: These findings underscore the need for health workers to also educate mothers on the VPDs and the benefits of immunization while educating them on the National Immunization Schedule. In addition, interventions for promoting immunization acceptance by mothers should be designed to involve their husbands.

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