Background: Condylomataacuminata is an infection caused by Human Papilloma Virus, rarely reported in infants and children. Podophylline as a treatment for this condition has been used cautiously in this age group. Objective: To report the cases of anogenital warts including condy lomataacuminata in infants and children and to evaluate the effectiveness and side effects of 15% podophyllin in treatment of genital warts. Patient and Methods: Thirty infants and young children were seen in Department of Dermatology and Venereology-Baghdad Teaching Hospital in this case descriptive and therapeutic trial, in the period from January 2011 to August 2012. Their ages ranged from 8-72 (30.43 ± 15.85) months, 20 females and 10 males with a female:male ratio of 2:1. The duration of the disease ranged from 1-12 (5.26 ± 4.00) months. All demographics data were recorded in this study. History and examination were carried out to all patients. Family members including mothers were assessed about the presence of any type of viral warts in other location of body. Podophyllin (15%) in tincture benzoin was applied once weekly to all viral warts and the parents advised to wash out after 2 hours of application. The number of applications was repeated until full recovery. Follow-up after recovery was carried out for 6 months to watch for any relapse and to record local or systemic side effects. Results: The clinical pictures were mostly acondylomata acuminata in a form of cauliflower like warts in 20 (73.33%) patients, while in 10 (26.77%) patients there were ordinary verruca vulgaris like warts. The location of warts was perianal in 23 (76.66%) patients, genital only in 2 (6.66%) patients, and mixed in 5 (16.66%) patients. Topical applications of podophyllin 15% gave a full recovery in 27 (90%) patients, while in 3 (10%) patients there was partial response. The number of applications ranged from 1-4 (2.7 ± 1.42) applications. Follow up for 6 months after recovery showed relapse in only one patient, and no side effects were reported in any patients. Conclusion: There is upsurge of cases of anogenital warts among infants and children. Podophyllin (15%) in tincture benzoin is an effective therapy and no local or systemic side effects were recorded in any case.

Background: Depressive symptom may associate with daily recommended dose of Isotretinoin for nodulocystic acne. Does reducing the dose will reduce the incidence of depressive symptoms is still not clearly understood. Study objective: To compare the types and frequency of depressive symptoms among patients with nodulocystic acne receiving three different low doses of isotretinoin (10mg daily, 20mg every other day, and 20mg daily). Study design: Open randomized clinical trial. Study setting: Dermatology clinic at Ibn Sina teaching hospital Patients & methods: 169 patients with severe nodulocystic acne were randomly assigned to one of three isotretinoin regimen groups as follows: 10 mg daily (n=46), 20mg alternate day (n=58), and 20 mg daily (n=65). After a month of treatment, patient assessed for degree of improvement of acne and incidence of depressive symptoms Results: The frequencies of depressive symptoms irrespective to group were as follows: crying in 36 (21.3%), anger in 35 (20.7%), sleep disturbance in 32 (18.9%), isolation in 29 (17.1%), and sadness in 20 (11.8%) of patients. The frequency of crying, anger and sadness were significantly rose with increase dose of isotretinoin from 10mg to 20mg daily (p-value equal to 0.02, 0.02, and 0.001 respectively).The summated depressive symptoms rose from (0.52 symptoms) in 10 mg daily to (1.19 symptoms) in 20 mg daily dose and the difference was statistically significant. Conclusion: Depressive symptoms increased gradually with increase dose of isotretinoin and reducing the dose to least effective dose is mandatory.