Background: Acne vulgaris is an inflammatory skin disease which is extremely common. Acne affects around 85% of teenagers, and its effects can persist into adulthood for some. It has been hypothesized that calprotectin plays an inflammatory function in acne vulgaris, and so contributes to its etiopathogenesis. Objective: The aim of the current study was to measure serum calprotectin in patients with acne vulgaris and finds any links between that measure and the severity of the underlying condition. Patients and methods: A total of 45 people with a diagnosis of acne vulgaris and 45 controls of the same age and sex participated in the study. They were selected from the Dermatology, Andrology, and STDs outpatient clinic at Mansoura University Hospitals between May 2021 and May 2022. Results: Acne vulgaris patients had considerably higher serum calprotectin levels with median of 18.9 compared with a median of 11 of the healthy volunteers (P <0.001). The GAGS (Global Acne Grading System) score was positively correlated with age (r= 0.341, P =0.022), body mass index (r= 0.538, P <0.001), acne duration (r= 0.461, P <0.001), and serum calprotectin (r= 0.874, P <0.001). GAGS scores was also positively correlated with serum calprotectin (r= 0.943, P <0.001), acne duration (r= 0.523, P <0.001), and age (r= 0.392, P =0.008). Conclusion: Acne vulgaris patients had increased serum calprotectin levels compared to control subjects, and they have a statistically significant relationship with disease severity, suggesting that calprotectin may be used as a chemical biomarker to determine disease severity.

Background: Acne vulgaris (AV) is an inflammatory disease of pilosebaceous follicles. It has multifactorial causes and is manifested as blackheads, papules, pustules, nodules, as well as cysts. The significantly greater serum hepcidin values among acne cases that do not develop post-acne scarring support its antifibrotic activities that were clarified by its capability of impeding transforming growth factor β1(TGF β1) induced Smad3 phosphorylation. Objective: The aim of the current work was to assess hepcidin gene polymorphism and plasma hepcidin level in acne vulgaris cases of varying severity with and without post-acne scaring. Patients and Methods: This case-control study included a total of 30 cases with AV with no post-acne scars, 30 cases with AV and post acne scar and 30 subjects of age and gender matched healthy controls, attending at