Objective: The main objective of this research was to formulate the fast disintegrating tablets (FDT's) of flurbiprofen incorporating superdisintegrants, isolated from natural sources such as Plantago ovata (PO) seeds, Lepidium sativum (LS) seeds, and agar-agar (malt agar).Methods: Superdisintegrants were isolated from their natural sources using reported methods. Swelling index and hydration capacity were determined for the natural superdisintegrants to know their disintegration capacity. The tablet formulations were designed using isolated natural superdisintegrants. The powder blends were evaluated for pre-compressional parameters such as angle of repose, bulk density, tapped density, Carr's index, and Hausner's ratio. FDT's were prepared by direct compression method. The compressed tablets were characterized for post-compression parameters.Results: All formulations had hardness, friability, weight variation, and drug content within the pharmacopoeial limits. The wetting time was 84-254 seconds, in vitro disintegration time was between 59.2 and 221 seconds, and in vitro drug release was as low as LS1 -11.80% to a maximum of PO4 -98.99% after 4 minutes of study. Among all, optimized formulation was PO4, as it showed good wetting time 84 seconds, fastest disintegration time 59.2 seconds, dispersion time 135 seconds, and drug release of 98.99% within 4 minutes. Conclusion:Flurbiprofen FDT's were successfully developed using isolated natural disintegrants. The natural disintegrants isolated showed promising results and can prove as effective alternative for synthetic disintegrants.

Galantamine hydrobromide is formulated in tablets and capsules prescribed through oral delivery for the treatment of Alzheimer’s disease. However, oral delivery of drugs can cause severe side effects such as nausea, vomiting, and gastrointestinal disturbance. In the present research work, Galantamine hydrobromide is formulated as proniosome gel by Coacervation phase separation method using different surfactants such as Tweens and Spans. Overall eight formulations were developed and evaluated for various parameters. The prepared gels were viewed by naked eye to observe the colour of gel. Microscopical observations of the gels showed vesicles of optimum size from 3.030 mm (P2) - 3.735 mm (P5). The gel also showed optimum rate of spontaneity in the range 9.60 mm3x1000 (P7) to 11.80 mm3x1000 (P4) and entrapment efficiency of vesicles in the range 66.15% (P5) to 86.92% (P3). The gels had pH in suitable range of skin (5.92-6.9). The in vitro drug diffusion studies revealed that the drug diffusion was affected by the various surfactants used. The rank order of surfactant effect on in-vitro drug diffusion was Tween 80 > Tween 60 > Tween 40 >Tween 20 > Span 80 > Span 60 > Span 40 > Span 20. The proniosomal gel containing Tween 80 showed maximum drug diffusion (99.24%) and the gel containing Span 20 showed minimum drug diffusion (71.74%). FT-IR studies of optimized proniosome gel P8 revealed the absence of any chemical interactions between drug and carriers used. Keywords: Galantamine hydrobromide, Proniosome gel, Coacervation phase separation method,   Surfactants, in vitro drug diffusion studies.