Background: Liver donation is a respectable human gift. It is essential that complications should be minimized as much as possible and must be safely performed. Aim of the work:To evaluate feasibility and safety of using CUSA for liver resection in living donor liver transplantation (LDLT) in comparison with harmonic scalpel. Patients and methods:This prospective study included 40 consecutive donors for LDLT held at Nasser Institute and Air Force Specialized Hospital during the period from September 2017 to September 2018.Results: Harmonic scalpel significantly reduced operative time (p=0.000) with a reduced blood loss (p=0.016), however it caused higher rate of biliary leakage (40% vs 15% respectively). On the other hand, CUSA showed lower bile leak leading to shorter hospital stay (p=0.000). Conclusion:Although harmonic scalpel is a faster method, CUSA is more effective and safer with a lower complication rate despite being cumbersome and need a longer learning curve.