<p class="abstract"><strong>Background:</strong> The impact of acute and sub lethal toxicity of synthetic Rogor on some biochemical and hematological parameters of a fish <em>Amphipnous cuchia</em> was estimated aquatic environment by various pollutants like pesticides, detergents, discharge of effluents and heavy metals induce changes in the biochemical, hematological and behavioral aspects of inhabitants. These pollutants cause serious effects on growth, biochemistry, physiology, neurochemistry and survival rate of the aquatic organism<span lang="EN-IN">. </span></p><p class="abstract"><strong>Methods:</strong> The present research work is one such attempt to investigate the effect of organophosphorous pesticide Rogor on biochemical and hematological parameters of fish <em>Amphipnous cuchia</em>. The main objective of this study was to investigate the level of AST, ALT, hematocrit and TLC in fish <em>Amphipnous cuchia</em> exposed 24 to 96 hours to four different concentrations of Rogor pesticide<span lang="EN-IN">.</span></p><p class="abstract"><strong>Results:</strong> Rogor toxicity resulted in a significant maximum increase (89.15%) in level of aspartate amino transferase (7.87±0.14<strong>/</strong>18.31±0.09) and alanine amino transferase (76.65%, 5.28±0.11<strong>/</strong>3.03±0.14) enzyme. Regarding to hematological parameter, significant maximum increase (77.12%) in total leukocyte count (27,400±298<strong>/</strong>15,470±286) and maximum decrease (66.07%) in hematocrit (6.20±0.04 <strong>/</strong>18.31±0.09) level was observed<span lang="EN-IN">.  </span></p><p class="abstract"><strong>Conclusions:</strong> In this study<strong> </strong>it is concluded that exposure to sublethal/lethal concentration of Rogor results in a significant alterations in different biochemical and hematological parameters and this kind of biochemical and physiological changes may directly affect the survivability of these fishes in these natural habitat.</p>

Type 2 diabetes mellitus affects millions of people worldwide. it is a disease considered a major public health problem in India. Vitamin D deficiency was found to be more prevalent in India despite having sunny weather. Its deficiency was found to be correlated with glycosylated hemoglobin. We conducted this study in an effort to better understand the relationship between vitamin D and glycosylated hemoglobin in non-obese. A total of 119 type 2 diabetes patients were recruited in this cross-sectional study. Patient details and biochemical parameters were collected. Participants were divided into groups with vitamin D deficiency 25(OH) D <20 ng/ml and without vitamin D deficiency 25(OH) D >20 ng/mL, Further subgrouping was done into male and female-only groups. Next, the subjects were divided into male and female groups according to their 25(OH)D levels. The finding showed a significantly higher level of HbA1c (8.02±0.35%) in the vitamin D deficiency group compared to (7.32±0.41%) without vitamin D deficiency (p <.001). And it was also true for creatinine (0.94±0.14 vs. 0.82±0.17) (p<.001) HbA1c and fasting plasma glucose both were significant negatively correlated with vitamin D deficient group only (r = - 0.49, p <.001), (r = - 0.40, p = 0.001).