The Tulamura anticline falls in the state Tripura, Northeast India. The anticline is extended up to neighbour country Bangladesh. The region is characterized by huge anticlines, normal faults and abnormally pressured formations which causes a wide margin of uncertainties in wildcat well planning and design. These geological complexities of Tulamura anticline make the drilling engineers more challenging. Therefore, a proper well design is essential in such a region to prevent blowout. Drilling engineer requires to maintain wellbore pressure between the pore pressure and fracture pressure to reduce the possibility of a kick and a formation damage. Pore pressure plays an important role to design a safe and economical well in such a high pressure and temperature reservoir. For wildcat drilling, only seismic data are available in the study area. There are various methods to predict pore pressure from seismic velocity data. Modified Eaton's method is widely used for the pore pressure prediction from seismic data in terms of the velocity ratio. Modified Eaton's equations may cause an error by manual selection of compaction trend line which is used to find normal compaction velocity. The main objectives of this study are to develop a new method to predict pore pressure and safe well design on the top of Tulamura anticline in terms of pore pressure. The new method is validated by a well-known method, modified Eaton's method, and RFT pressure data from offset wells. An excellent match with pore pressures estimated from RFT pressure data and predicted by new model along with modified Eaton's method is observed in this research work. The efficiency and accuracy level of the hybrid model is more as compared to other methods as it does not require compaction velocity data; thus, an error caused by manual compaction trend can be eliminated. Pore pressure predicted by new method indicates result up to the 6000 m, which is up to the basement rock. The predicted pore pressures by new method are used as an input to calculate the fracture pressure by Hubbert and Willis method, Mathews and Killy method and modified Eaton's method. Equivalent mud weight selection is carried out using median line principle with additional 0.3 ppg, 0.3 ppg and 0.2 ppg of swab pressure, surge pressure and safety factor, respectively, for calculation of all casing pipes. Casing setting depths are selected based on pore pressure gradient, fracture pressure gradient and mud weight using graphical method. Here, four types of casing setting depths are selected: conductor, surface, intermediate and production casings at 100 ft, 6050 ft, 15500 ft and 18,500 ft, respectively, by new methods, but the casing setting depths for intermediate are at 13500 ft in the case of modified Eaton's method. The casing policy is selected based on burst pressure, collapse pressure and tension load. For each casing, kick tolerance in bbl is determined from kick tolerance graph to prevent the blowout. Finally, comparative safe and economical wells are designed on the top of Tulamu...