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In the Unani system of medicine, the seven fundamental principles (Umür Tabi’iyya) i.e. Arkan (basic constituents), Mizaj (Temperament), Akhlat (Humours), A’da’ (Organs), Arwah (Vital pneumas), Quwa (Faculties) and Afal (Functions) are not only responsible for the existence of human body but for the maintenance of health too. Any alteration in these principles could lead to disease or even death. Amongst them, the concept of four humours is momentous in the diagnosis and management of diseases, as it covers every single aspect of health and diseases. Hence innumerable diseases are classified depending on alteration in humours. Owing its philosophical and scientific facts Unani physicians believe on this classical concept and use it in their practice too. In the present study alteration and discordance of Akhlat i.e., Imtilä Ba Hasbul Quwa and Imtilä Ba Hasbul Awaiya and their alarming features have been described in detail. Thus, with the help of logical and scientific parameters the study will aid in better understanding of the concept of akhlat, their effect on health and diseases too.

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