Physiological responses of Oryza sativa L. to lead excess (10 and 50 μM) were studied in a hydroponic system after 48-and 96-h exposure. Accumulation of Pb in stressed rice shoots was concomitant with an increased metal concentration in the growth media and duration of exposure. The Pb stress resulted in an enhanced lipid peroxidation accompanied by altered activities of antioxidants. A substantial increase in α-tocopherol content of the Pb stressed rice shoots was observed suggesting its important role as an antioxidant. Among the antioxidant enzymes studied, activities of superoxide dismutase (SOD) and ascorbate peroxidase (APX) increased in the Pb-treated rice shoots, whereas that of catalase (CAT) declined. Activity of an important ascorbate-glutathione cycle enzyme, glutathione reductase (GR), also increased significantly in the Pb-treated shoots. The results suggest that Pb toxicity resulted in induction of oxidative stress in rice shoots, and α-tocopherol accumulation and upregulation of SOD, APX, and GR activities play an effective role in acclimatization to Pb stress.

No abstract

Resveratrol, a natural stilbene found in grapes and wines exhibits a wide range of pharmacological properties. Resveratrol is also known as a good chemopreventive agent for inhibiting carcinogenesis processes that target kinases, cyclooxygenases, ribonucleotide reductase and DNA polymerases. A total of 19 analogues with an amide moiety were synthesized and the cytotoxic effects of the analogues on a series of human cancer cell lines are reported. Three compounds 6d, 6i and 6n showed potent cytotoxicity against prostate cancer DU-145 (IC50 = 16.68 μM), colon cancer HT-29 (IC50 = 7.51 μM) and breast cancer MCF-7 (IC50 = 21.24 μM), respectively, which are comparable with vinblastine. The resveratrol analogues were synthesized using the Heck method.

To cite this article: Azmi, M. N. et al. (2021). Synthesis of indolostilbenes via FeCl 3promoted oxidative cyclisation and their biological effects on NG108-15 cell viability and H 2 O 2 -induced cytotoxicity.

In the title compound, C17H17NO2, the phenyl­ene rings are nearly coplanar [dihedral angle 7.3 (1)°]. The acetamido group is twisted out of the plane of the aromatic ring in order to form an N–H⋯O hydrogen bond to the acetamido group of an adjacent mol­ecule, generating a helical chain running along the b axis.