The distribution system has the most portion power loss compared to the transmission and generation systems. One of the effective methods to reduce the power loss in the system is by reconfiguring the existing network. In distribution system, there are two types of switches, which are sectionalizing switches and tie-switches. Reconfiguration process changes the status of those switches until the objective is achieved. In this study, the reconfiguration method is proposed for distribution system using the Cuckoo Search Algorithm (CSA) method. The system used is a standard IEEE 33-bus radial distribution system. The main objective is to reduce the power loss in the system while satisfying the distribution constraints. The proposed method is used to give an optimal configuration of distribution network for power loss reduction and its validity is done by comparing it with Particle Swarm Optimization (PSO).