Over the past few decades, human activity monitoring has grabbed considerable research attentions due to greater demand for human-centric applications in healthcare and assisted living. For instance, human activity monitoring can be adopted in smart building system to improve the building management as well as the quality of life, especially for the elderly people who are facing health deterioration due to aging factor, without neglecting the important aspects such as safety and energy consumption. The existing human monitoring technology requires additional sensors, such as GPS, PIR sensors, video camera, etc., which incur cost and have several drawbacks. There exist various solutions of using other technologies for human activity monitoring in a smartly controlled environment, either deviceassisted or device-free. A radio frequency (RF)-based device-free indoor localization, known as device-free localization (DFL), has attracted a lot of research effort in recent years due its simplicity, low cost, and compatibility with the existing hardware equipped with RF interface. This chapter introduces the potential of RF signals, commonly adopted for wireless communications, as sensing tools for DFL system in human activity monitoring. DFL is based on the concept of radio irregularity where human existence in wireless communication field may interfere and change the wireless characteristics.