Background: Majoon Najah is a polyherbal traditional Unani formulation recommended for the treatment of neurological disorders. To evaluate antiepileptic and antidepressant activity of majoon najah and majoon najah extract in experimental animals. Methods: Anticonvulsant activity was tested using maximal electroshock induced convulsion in male sprague dawley rats using diazepam 3 mg/kg, p.o. as positive control. Pentylenetetrazole induced convulsion in swiss male albino mice was performed using phenytoin 25 mg/kg i.p. as positive control. The antidepressant activity of MN was evaluated using forced swim test model in male using Imipramine 20 mg/kg, p.o. as positive control. Results: Antiepileptic study data showed reduction of all parameters like, tonic hind limb extension, clonic convulsion and stupor; however the values were not found statistically significant at all tested dose levels. The results of forced swim test model indicated that majoon najah effectively showed significant (P<0.001) reduction in immobility duration in animals treated with majoon najah classical at dose 500 mg/kg bw and 1000 mg/kg bw as compared to control rats. Conclusion: Based on above findings, it may be concluded that majoon najah did not showed effectiveness in epilepsy however, the results evident that majoon najah is a potential Unani formulation having antidepressant activity which may be preferred as an alternative therapy over modern medicine to treat depression.

CASE REPORTprotein (40.94 mg/L) were elevated. Prothrombin time (15.1 seconds and international normalized ratio of 1.3) and activated partial thromboplastin time (18.4 seconds) were normal. Electrocardiogram was normal. Abdomen ultrasound showed normal size kidneys with altered echotexture. The patient was diagnosed with AKI secondary to rhabdomyolysis and taken up for hemodialysis. Serum phenytoin and phenobarbitone levels were available after the first session of hemodialysis. The total phenytoin level was 17 µg/mL (therapeutic level 10-20 µg/mL), and the total phenobarbitone level was 9.2 µg/mL (therapeutic level 15-40 µg/mL). His tracheobronchial aspirate culture showed Acinetobacter, for which an appropriate antibiotic was given. The patient subsequently improved with alternate-day hemodialysis and vigorous intravenous (IV) hydration