No abstract

No abstract

No abstract

Herbal medicines are an important and growing part of International pharmacopeia. Research and testing enhance our understanding of their medical properties, making them a safer alternative or preferable option to allopathic medication. Plant-derived pharmaceuticals are gaining popularity due to the belief that "green medicine" is safer and more trustworthy than expensive synthetic drugs. This study aimed to evaluate the antimicrobial and anticancer potential of the methanolic leaf extract of Artemisia absinthium against human lung cancer A549 cell line by well diffusion method and MTT assay, respectively. The A. absinthium leaf extract showed the highest activity against Enterococcus faecalis (20 ± 0.7 mm), and Escherichia coli (18 ± 0.8 mm), followed by Pseudomonas aeruginosa (16 ± 0.6 mm), Candida albicans (14 ± 0.9 mm) and Staphylococcus aureus (13 ± 0.8 mm), with MIC values 128, 128, 128, 256 and 256 µg/mL respectively. The methanolic extract of A. absinthium showed significant (p ≤ 0.05) cytotoxicity against the A549 cancer cell line with an IC50 value of 36.8 µg/mL. The present study's findings give strong evidence for using the methanolic leaf extract of A. absinthium as an effective ethnomedicinal agent and a possible candidate for treating various human diseases and a potent bioactive agent in anticancer medications.

Currently, medicinal plants are gaining importance in pharmaceutical and scientific communities. Medicinal plants are the most abundant natural source of valuable phytochemicals, which can help treat human diseases. The present study aimed to do phytochemical profiling and assess the antimicrobial and anticancer activity of the methanolic leaf extract of Rosmarinus officinalis. The photochemical profiling of R. officinalis leaves was done by GC-MS analysis. Twenty-six compounds were identified from the leaf extracts with great significance in pharmaceutical science for therapeutically efficient formulations to combat various diseases. The antimicrobial activity was done by the well diffusion method, while the anticancer potential against the A549 lung cancer cell line by MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The highest zone of inhibition was seen against Escherichia coli ATCC 11229 (21 ± 0.7 mm), Enterococcus faecalis ATCC 29212 (19 ± 0.8 mm), Candida albicans ATCC 10231 (18± 0.6 mm) followed by Staphylococcus aureus ATCC 25923 (18 ± 0.8 mm) and Pseudomonas aeruginosa (11 ± 0.5 mm) with MIC values ranging from 128 to 256 µg/mL. R. officinalis demonstrated significant (p ≤ 0.05) anticancer activity against the A549 cancer cell line with IC50 values of 39.70 and 33.60 µg/mL for 24 and 48 hours, respectively. The methanolic extract of R. officinalis can be a potential antimicrobial and anticancer agent and a vital resource for developing new drugs.