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Introduction: Chronic kidney diseases are one of the problems that threaten people's physical and psychological health. Aim: The present study aims to compare the effectiveness of acceptance and commitment therapy and dialectical behavioral therapy on coherent self-knowledge, emotional regulation and life quality of hemodialysis patients. Method: The present study is a semi-experimental one with a pre-test, post-test and a control group design. The statistical population of this research was hemodialysis patients of Shafa Hospital and Javad Al-Aima Clinic in Kerman in 2022. For this research 45 hemodialysis patients were selected using convenience sampling and randomly placed into two experimental groups of effectiveness of acceptance and commitment therapy and dialectical behavioral therapy and a control group. The research tools included Qorbani Coherent Self-knowledge (2008), Gross Emotional Regulation (2003) and World Health Organization Life Quality (1996) Questionnaire. The collected data were analyzed using covariance analysis or ANACOVA statistical exams, Tukey's b post Hoc exam using SPSS-24 statistical software. Results: The result of covariance analysis showed significance difference between the experimental and control groups as (P<0.001). Compare to the control group, improvements were observed in coherent self-knowledge, emotional regulation and life quality of hemodialysis patients participated in both experimental groups. Conclusion: Acceptance and commitment therapy and dialectical behavioral therapy, are proper methods in increasing coherent self-knowledge, emotional regulation and life quality of hemodialysis patients. It is recommended that these approaches can be used alongside other medical treatments.