Amphiphilic block copolymers tend to self-assemble in an aqueous phase and form micelles. These polymeric micelles have nanoscale, high thermodynamic and kinetic stability and can solubilize hydrophobic substances; therefore, they may be applied to separation systems, drug delivery systems, pharmaceuticals, or emulsion stabilization (1-3). Polymeric micelles composed of block copolymers show a core-shell micellar structure with a hydrophobic inner core surrounded by a hydrated outer shell in aqueous solution. Hydrophobic drugs can be incorporated into the hydrophobic inner core and the hydrated outer shell helps prevent opsonization of the carrier and uptake by the reticu- The objective of this work was to study the effect of fatty acid chain length grafted to methoxy poly(ethylene glycol) (mPEG) on self assembling properties of micelles for etoposide delivery. Three amphiphilic copolymers were synthesized using mPEG, myristic acid, stearic acid and behenic acid through an esteric linkage. The particle size and zeta potential of the micelles were determined by the dynamic light scattering method. Etoposide was loaded into micelles by film casting using various drug/polymer ratios. Drug release was studied by the dialysis method. The structure of copolymers was confirmed by 1 H NMR and FTIR. Central micellar concentration (CMC) measurements showed that the longer hydrophobic chains formed more thermodynamically stable micelles. Among the prepared copolymers, etoposide showed the highest solubility in the mPEG-behenic copolymer. Drug loading efficiency depended on the hydrophobic chain length and drug/polymer ratio. The highest drug loading efficiency was found in mPEG-myristic micelles with 1:20 drug/polymer ratio. Micelles released 80 % of loaded drug within about 5 h.