Introduction: Ulcerative colitis is a chronic inflammatory disease of indefinite etiology having relapsing and remitting course. Assessing inflammatory activity via different scoring systems along with clinical correlation plays an important role in the diagnosis and surveillance of ulcerative colitis patients. Histopathological findings should be correlated with the clinical, endoscopic and radiological findings to exclude other causes with similar symptomatology, hence improving the management of patients with UC. Aims and objective: To determine the clinical features and histological features in relapsed patients of ulcerative colitis. Place and duration of study: Department of Pathology, Histopathology section, Sheikh Zayed hospital Lahore, from 25th February, 2016 to 25th February, 2017. Materials and methods: One hundred and ninety cases underwent endoscopic colonic biopsies from the three sites proximal colon, distal colon and rectum. Results: Out of one hundred ninety patients majority patients presented with vague abdominal pain 105(55.3%) followed by bleeding per rectum 74(38.9%). Most commonly seen histological feature is cryptitis 189(99.5%) succeeding chronic inflammation 188 (98.9%). Conclusion: Relapsed patients predominantly presents with vague abdominal pain. Cryptitis is most commonly seen histological feature in relapsed patients of ulcerative colitis. Keywords: Inflammatory bowel disease, Ulcerative colitis , Crohn’s disease

Objective: To determine the proportion of histological features and histological feature predicting frequency of elapse in known patients of ulcerative colitis. Methodology: One hundred and ninety cases each had endoscopic colonic biopsies from the rectum, distal colon, and proximal colon. Study Design: Retrospective Case series Setting: Sheikh Zayed Hospital Lahore, Department of Histopathology, from February 25, 2016, to February 25, 2017. Results: The majority of patients complained of generalized abdominal pain (55.3%). The commonest histological feature is cryptitis 189(99.5%). Majority patients with basal plasmacytosis 38(42.2%) and crypt abscess 36(29.8%) relapsed at 4th month. Conclusion: Histological features basal plasmacytosis and crypt abscess are of prognostic importance. A greater chance of relapse can be predicted in patients with increased number of basal plasma cells and cryptitis. These findings will help in further management of ulcerative colitis patients. Keywords: Inflammatory bowel disease, Ulcerative colitis, Remission, Relapse