Aim: The study aimed to evaluate the effect of an educational program about cerebral palsy management on mothers' performance. Design: A quasi-experimental research design was used in conducting this study. Subjects: A consecutive sampling consisted of 50 mothers that were attending to physiotherapy clinic at genetic counseling center in Port Said city. Setting: The study was conducted in physiotherapy clinic at genetic counseling center in Port Said city. Tools of data collection: The data was collected by self-administer questionnaire, Mothers reported practices regarding care of their children. Results: Increased total knowledge of mothers to 94% in post intervention phase, while declined to 54% at follow up phase. Also improvement in the overall practices of the studied mothers throughout the program phases. Conclusion: Both the mothers' total knowledge score and their overall reported practices increased once the program was implemented. Recommendations: Continuous health education and counseling programs for mothers on the problems associated with cerebral palsy and how to dealing with it should be provided.