Objectives: This study aimed to figure out the relation between pattern and density of fingerprint and ABO blood group and subgroups. Material and Methods: We have conducted a study on 221 healthy Egyptian individuals of both sexes in the age range from 18 to above 60 years old with different ABO blood groups. Fingerprints were obtained by the ink method on Standard cards; a magnifying hand lens was used to study the patterns. Epidermal ridges from fingerprint samples were counted within a 5x5mm square is drawn on transparent film. Anti-A, Anti-B, and Anti-D reagent were used to determine the blood group. Results: Frequencies of different fingerprint patterns showed that the most frequent were loops while the least frequent in both hands were composite. Loops were more frequent in the left than the right hand. Whorls were most frequent in the right than left hand. Loops were more frequent in O, followed by AB and AB. where whorls were more frequent in A, followed by O, AB and B. Loops were most frequent with O+ and whorls with A+. The highest density was in individuals with blood group B, and the least one was with blood group AB. Conclusion: There was an association between distribution of fingerprint patterns, density and the blood group and subgroups in our opinion, and blood group of a person is possible based on his/her fingerprint patterns and density