Post-intensive care syndrome (PICS) is a newly acquired long-term cognitive impairment. It includes major physical, mental and functional disabilities that affect the critically ill patients' experience This paper presents a complete research design (from medical and technical points of views), test conduction, and evaluate the effect of implementing a designed structured technology-based therapy (STBT) on preventing PICS among critically ill patients. Authors called the new STBT platform, cognition gymnastics (CogGym). CogGym is an android-based devices platform with an Arabic user interface (UI) that contains many flexible and easy to use games designed specifically for the Arab critically ill patients. In conclusion, CogGym enables them to continue to do therapeutic gymnastics after the therapist leaves the room to keep working toward rehabilitation goals.Reference to this paper should be made as follows: El-Hady, M.M. and Shohieb, S.M. (2020) 'A comprehensive design of a structured technology-based therapy to prevent post intensive care syndrome (CogGYM platform)', Int.