Synthesis of some 1,3,4-thia-, oxadiazol and 1,2,4 triazole incorporated the biologically active and the pyrazolopyridine derivative. Molecular modeling and docking of the active compounds into AKR1C3 complexed with its bound inhibitor indomethacin using Molsoft ICM 3.4-8C program were performed in order to predict the affinity and orientation of the synthesized compounds at the active site.
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