Hair dye poisoning is a significant emerging problem in Upper Egypt. The main component of hair dye causing toxicity is para-phenylenediamine (PPD). Ingestion of PPD could be accidental or suicidal. After oral intake, it is metabolized in the liver into N-mono-(MAPPD) and N, N′diacetylated (DAPPD) metabolites. Tissue damage after PPD ingestions occurs due to increased free radical and oxidative stress that depletes tissue glutathione. Cardiac toxicity is a complication of PPD poisoning. It could be manifested by hypotension, different arrhythmia; besides, myocarditis and elevated cardiac biomarkers were also found. Serum and urinary levels of PPD, N-acetyl-p-phenylenediamine (MAPPD), and N--diacetylp-phenylenediamine (DAPPD) were measured by HPLC. A prospective cohort study was planned to determine the relationship between the serum and urinary PPD, N-acetyl-pphenylenediamine (MAPPD) and N, on -diacetyl-p-phenylenediamine (DAPPD) levels with cardiac manifestations of the poisoned patient. Forty patients completed the diagnosis to have acute poisoning following hair dye ingestion. PPD and its metabolite concentrations did not show any significant correlation with the prevalence of cardiac toxicity and could not predict its occurrence among studied patient (p-value< .05

Background: Bisphenol A (BPA) is an industrial chemical associated with several health effects and exposure to BPA remains poorly characterized in the developing countries. In this pilot study, we evaluated BPA exposure, assessed some sources of exposure and its health effects among Egyptian children. Methods: Total BPA concentration was measured in two groups of spot urinary samples of ADHD (N = 24) and apparently healthy control (N = 24) children. Questionnaire data regarding food storage behaviors to assess potential sources of exposure was collected. Results: ADHD children exhibited higher urinary BPA concentrations; with median value of 24.5 µg/L. Reported consumption of canned food was a significant predictor of increasing concentrations of urinary BPA. Conclusion: The reported relatively high urinary BPA concentrations within Egyptian children with ADHD and the significant association between the canned food consumption and the increased urinary BPA concentration highlights the need to modify food and consumer product patterns to prevent potential adverse health outcomes in the future.