Abbreviations: Col7, collagen type VII; DEB, dystrophic epidermolysis bullosa; RDEB-I, inversa recessive dystrophic epidermolysis bullosa

‘Neuro-Behçet’ is not a rare disease in the United Arab Republic, as it was possible to detect 22 cases in just 3 years. The detection of the true incidence of Behçet syndrome and the true percentage of ‘Neuro-Behçet’ depends on the combined search by all specialists concerned. The similarity between the presenting clinical pictures and the accepted, though sometimes etiologically vague, clinical syndromes is discussed in an attempt to render the consideration of ‘neuro-Behçet’ in differential diagnosis reasonably acceptable. This consideration is justified in the presence of the oro-genital and ocular manifestations, or a history thereof. The mere affection of the nervous system does not indicate a bad prognosis. The prognosis depends, as in many other neurological diseases, on the site of the lesion. Initial big doses of systemic steroids, with a permanent maintenance dose, are recommended. Further evidence is discussed favouring autoimmune pathogenesis, possibly triggered by a virus infection.

Background: Studies on the co morbidities seen with lichen Planus Pigmentosus (LPP) are limited. Aims: We sought to determine the prevalence of auto immune diseases (AD) associated with LPP. Methods: A total of 30 patients with LPP and 30 age and sex matched controls were examined. Both groups were evaluated for the presence of AD using physical examination and immunological tests. Results: We collected 30 LPP patients. There were 9 men and 21 women. Prevalence of AD was higher in LPP patients (40.0%) than in the control group (3.3%). LPP was significantly associated with AD, the age and gender adjusted OR was 22.9; P: 0.005. Twelve patients had an associated AD. There was no statistically significant difference between the group with ADs and without ADs concerning the sex, the age of onset of the disease, the extent of the lesions and the evolution. The immunological tests were positive in only one patient. Limitations: This study was performed in a little sample with a geographically restricted population. Conclusion: We found a frequent association of LPP with ADs. We suggest that autoimmunity might be a pathogenic factor of LPP.

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