SummaryThe focus when analyzing the environmental requirements and impacts of the economic system is usually placed on production activities. But all production is associated with final consumption, and recently many studies have also been dedicated to final consumption. This article comprehensively reviews the biophysical assessment of households from the point of view of materials and energy required and emissions and wastes resulting from household consumption patterns. Although the aggregation bias and methodological variability make comparisons difficult, some patterns can be recognized. Results show that for many Organization for Economic Cooperation and Development (OECD) and a few developing countries, household metabolism has been mainly assessed from the energetic perspective, stressing household responsibility for emissions of greenhouse effect gases and climate change. Few studies deal with other emissions and wastes. There is a lack of information about material requirements, too. Environmental input-output (I-O) analysis and life cycle assessment are the methods usually employed, together with the use of economic, environmental, and expenditure information. Information about direct inputs and outputs is complemented with data on the environmental requirements associated with the consumption of goods and services. Multiregional I-O techniques have been used to capture upstream requirements in an attempt to avoid errors owing to truncation and domestic technology assumptions. Housing, food, and mobility are the most important consumption categories, but the shares of these categories in the requirements are different according to environmental, socioeconomic, and demographic factors. Finally, challenges for further research are discussed based on the need for new methodological developments, as well as the potential of the metabolic narrative to elaborate information relevant to sustainable consumption policies.

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Background: Aberrant signaling by ErbB-2 (HER 2, Neu), a member of the human Epidermal Growth Factor (EGF) receptor family, is associated with an aggressive clinical behaviour of carcinomas, particularly breast tumors. Antibodies targeting the ErbB-2 pathway are a preferred therapeutic option for patients with advanced breast cancer, but a worldwide deficit in the manufacturing capacities of mammalian cell bioreactors is foreseen.

las relaciones del sistema económico con los sistemas naturales .

Dealing with an increasing population is challenging the global food system not only in productive terms, but also through the associated environmental pressures. A growing diagnostic effort is being made by global and national agencies. Innovative approaches are needed to support effective policy efforts. This study aims to illustrate the potentialities of the household metabolism approach in the diagnosis of the environmental pressures derived from household food consumption, using the Spanish regions and the effects of the 2008 crisis as case studies. The direct information concerning food consumption in physical terms provided by the Spanish household budget survey is used to estimate some relevant environmental pressures (food losses and waste along the food chain, as well as water and carbon footprint) for the Spanish food system at a sub-national level. These data are directly translated into differences in environmental pressures and compared with other dietary profiles. Furthermore, the physical information of environmental pressures is related to household socio-economic status, showing the potentialities of the association with household socio-economic information. Finally, our data illustrate with some examples how the economic crisis has acted as a driver of change in food consumption, promoting a better environmental performance at the cost of poorer diets.