SUMMARYPatients with glucose-6-phosphate dehydrogenase (G6PD) deficiency are not represented in clinical trials for heart failure. Moreover, many of the recommended medications can cause haemolysis in this group of patients. We present the case of a 71-year-old woman with G6PD deficiency admitted for acute non-ischemic heart failure with reduced ejection fraction. Our experience showed that a combination of ethacrynic acid and spironolactone is safe and effective for relief of volume overload in this group of patients. Studies are needed to determine whether the morbidity and mortality benefits of established heart failure regimens extend to patients with G6PD deficiency. BACKGROUND

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Hypertensive encephalopathy (HE) isa clinical syndrome that occurs infrequentlyin children and is oftenunderdiagnosed. We review fourpatients with HE and describe theirclinical presentation and radiologicalfindings on computed tomography(CT). Our cases demonstrate typicalfeatures on CT and correlate clinicallywith the syndrome of HE. Promptrecognition of the syndrome aids inearlier diagnosis and treatment, andhence proves beneficial to the patient.