The increase in technology use in Africa provides an opportunity to advance training delivery. The World Health Organization Regional Office for Africa (WHO-AFRO) and the Centers for Disease Control and Prevention developed an electronic learning course targeting district and national surveillance health officers responsible for disease prevention, detection and response functions. The e-Learning course is based on the Integrated Disease Surveillance and Response framework which incorporates core capacities for the International Health Regulations (2005) and supports the prevent-detect-respond goals of the Global Health Security Agenda. The course was piloted in 7 African countries, and will be implemented in 47 WHO-AFRO countries.