Background:There is limited data about current utilization of miniscrews in orthodontic practices in India. The purpose of this survey was to obtain information on clinical utilization of miniscrews among orthodontists in India.Materials and Methods:A survey questionnaire was prepared and mailed to 2100 qualified and registered orthodontists in India.Results:A total of 1691 orthodontists responded to the survey, with a response rate of 80.52%. Among them, 952 (56.3%) had never used miniscrews in their clinical practice. Seven hundred and thirty-nine (739) (43.7%) had utilized miniscrews in their treatment, at some point of time. Among the orthodontists who used miniscrews, 463 (62.65%) used a surgical guide for positioning the miniscrews and 276 (37.35%) placed miniscrews without a surgical guide. Six hundred and thirty-four (634) (85.79%) orthodontists placed the miniscrews personally while 105 (14.21%) utilized the help of other specialists for placing the miniscrews. Among the orthodontists who used miniscrews, 76 (10.28%) utilized the help of oral surgeon to place the miniscrews while 29 (3.93%) utilized the help of periodontists to do the procedure.Conclusion:Miniscrews are a useful addition to the orthodontic armamentarium. The major indication for miniscrew was indirect anchorage in critical anchorage cases. The most important factors in determining the clinical utilization of miniscrews as a part of the treatment modality depends upon operator training and skill; fear of complications, patient refusal to accept miniscrews and the clinician's preference for conventional methods without unnecessary invasive procedure.

Aflatoxin B1 is a carcinogen produced by Aspergillus flavus and a few related fungi that are often present in many food substances. It interacts synergistically with Hepatitis B or C virus (HBV, HBC) infection, thereby increasing the risk of hepatocellular carcinoma (HCC). The G to T transversion at the third position of codon 249 (AGG) of the TP53 gene, substituting arginine to serine, is the most common aflatoxin-induced mutation linked to HCC. This study examined mutations in TP53 by PCR-RFLP analysis and by measurement of an aflatoxin-albumin adduct as a biomarker for human exposure of aflatoxin B1 by indirect-competitive ELISA, in samples collected from healthy controls as well as patients with hepatitis in Hyderabad, Andhra Pradesh, India. A total of 238 blood samples were analyzed the presence of the G to T mutation. Eighteen of these samples were from HBV-positive subjects, 112 of these were from subjects who had HBV-induced liver cirrhosis, and 108 samples were taken from subjects without HBV infection or liver cirrhosis (control group). The G to T mutation was detected in 10 samples, 8 of which were from subjects positive to both HBV and aflatoxin-albumin adduct in blood (p=0.07); whilst two were from individuals who were HBV-negative, but positive for the aflatoxin-albumin adduct (p=0.14). The aflatoxin-albumin adduct was detected in 37 of 238 samples, 29 samples were from HBV-positive subjects and eight were from individuals who were positive for both HBV and the TP53 mutation (p=0.07). The concentration of aflatoxin-albumin adduct ranged from 2.5 to 667pg/mg albumin. Despite low incidence of the G to T mutation, its detection in subjects positive to aflatoxin-adducts is indicative of a strong association between the mutation and aflatoxin exposure in India.

Introduction: Colposcopy is done to detect cervical cancer and changes that may lead to cervical cancer. We aimed our study to observe the incidence of different pathologies of the cervix in Colposcopic specimens in Rajshahi Medical College of Bangladesh. Materials and Methods: Retrospective data were collected from the routine histopathological laboratory in the department of pathology Rajshahi Medical College and were recorded during a study period of 1 year (July 2019 to June 2020). Observations: Colposcopic biopsy is one of the commonest diagnostic procedures for assessing cervical Pathosis. Out of 641 specimens more than half, 365 specimens (56.50%) were Chronic Cervicitis. In present study, Chronic Cervicitis with squamous metaplasia and Invasive squamous cell carcinoma became the 2nd, 16.39% (105 specimens), and 3rd, 13.42% (86 specimens) most pathology involving the cervix. Cervical polyp, Endocervical and Leiomyomatous constitute 6.39% and 1.57% of the specimens respectively. 4.36% (28 specimens) of the study sample were the Intraepithelial neoplasia (CIN I, CIN II, CIN III). Adenocarcinoma and Clear cell carcinoma constitute 0.79% and 0.16% of the study specimens. 50 % of the cervical squamous cell carcinoma was moderately differentiated and well-differentiated and poorly differentiated squamous cell carcinoma constitutes 30.23% and 19.77% respectively. Conclusions: Colposcopic examination of cervical biopsy specimens helps to detect the exact causes and underlined pathology

This retrospective study of histopathological specimens was done at the Department of Pathology of Rajshahi Medical College, Bangladesh, from July 2019 to June 2020, emphasizing challenges and diagnosis outcomes. Data obtained from their case notes included age at admission, the site from where the specimens were collected, and histopathological diagnosis.  Out of the 2026 histopathology samples, chronic cervicitis constitutes about 50% of the cases. Serous cystadenoma (about 1/4th cases) was common among ovarian pathology. 54.16% of the breast pathology exhibited Invasive ductal carcinoma. Reactive follicular hyperplasia and lymphoma constitute 49.44% of the lymph node pathology. About 80% of the gall bladder pathology was chronic cholecystitis, and metastatic adenocarcinoma was the commonest pathology involving the liver. Squamous cell carcinoma constitutes about 40% of the skin pathology. Osteosarcoma, osteochondroma, and giant cell tumor were the common pathologies involved in bones. Transitional cell carcinoma constitutes about 45% of urinary bladder pathology, and renal cell carcinomas were the commonest pathology of the kidney. Adenocarcinoma constitutes about 45 % of stomach pathology, 28% of small intestine pathology, and 14% of large intestine pathology.  Histopathological specimens at the pathology Rajshahi Medical College department with a wide range of pathologies are a major problem. From this study necessity of screening programs for early cancer detection appeared as a time-demanding issue. TAJ 2021; 34: No-1: 16-25

This cross-sectional, descriptive observational study was carried out for a period of 24 months from January 2014 to December 2015 in the Department of Pathology and Department of Surgery, Rajshahi Medical College, Rajshahi for estimation of serum 19-9 level in total fifty four patients. Histopathological Staging was correlated with the preoperative values of serum CA 19-9 level. Data were collected by face to face interview, clinical examination and findings of laboratory investigations. Preoperative serum CA 19-9 levels were estimated by Enzyme Linked Immunosorbent Assay (ELISA) Method. The study revealed that the colorectal carcinoma was highest in the 5th and 6th decade and rectal area (46.3%) and male predominance was observed with male to female ratio being 3:2. A higher incidence of abnormal CA 19-9 level was found in Dukes’ D (100%) and Dukes’ C (84%) diseases than in Dukes’ B (76%) and Dukes’ A (75%) stages. The sensitivity of CA 19-9 in correctly detecting advanced stage CRC carcinoma from those who had early stage of the disease is (36/44) × 100 = 81.8% and its specificity in correctly excluding those who did not have advanced disease is (2/10) × 100 = 20%. The overall diagnostic accuracy is calculated to be (36 + 2)/54 = 70.37%. Regarding diagnostic values for colorectal carcinoma elevated level of serum CA 19-9 can be considered as an important diagnostic tool for differentiating advanced stage of colorectal carcinoma from its early stage TAJ 2020; 33(1): 35-40