Therapeutic studies with cross‐transplant cross‐transfusion were begun in 1966 and have included 56 patients with melanoma, 2 with renal cell carcinoma, 3 with osteogenic sarcoma, 2 with colon cancer, and 1 with synovial sarcoma. Minced fragments of viable tumor were implanted subcutaneously into ABO‐Rh matched pairs with similar tumor on days 1 and 10, followed on the 14th day by 3–10 daily cross‐transfusions of plasma and white blood cells. Subsequently, intradermal implants of viable tumor cells grown in tissue culture have been used, some with added BCG. Complete responses have occurred in 3 patients with melanoma lasting 12, 46, and 51 months; the latter 2 remain alive and well. Partial response occurred in 6 others. Three melanoma patients with a poor prognosis were immunized prophylactically following primary surgical treatment. These 3 developed antibodies (shown by flourescence) against their tumor and remained free of disease—1 for 2 years and 2 for 1 year. Complications have mainly resulted from transfusion incompatibility. Transfer factor is now being used to avoid this problem. Two patients died following the seventh transfusion from complications probably related to treatment.

A five-year review at ethanol ingestions in children at Charity Hospital of Louisiana at New Orleans, revealed nine cases with blood ethanol levels in excess of 21.7 mmole/L (100 mg/dL); none resulted in death. We describe four patients in whom the blood ethanol levels were potentially life-threatening. In one case, we were able to follow the affected child's blood ethanol level serially; the rate of decrease was about twice that reported for an adult.

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A previously unsuspected cytoplasmic organoid, fibrillar in nature, was discovered by Bessis and Breton-Gorius. This structure exhibits a very high degree of structural organization, and appears as a barrel-shaped fibrillar formation, opened at both ends and enclosing an associated granular component within. Comparable fibrillar formations are rarely found in normal cells, even in the simplest form of a few closely packed fibrils. In its highest degree of structural organization, the whorl, the fibrillar formation has been found only in the blast or promyelocytes stages. Although the overall dimensions of this structure are well within the resolving limits of the light microscope, it is not visible in fresh, Wright stained or Giemsa stained preparations.