Background: CHADS2 and CHA2DS2-VASc scores are widely used in clinical practice and include similar risk factors for the development of coronary artery disease (CAD). It is known that factors comprising the newly defined CHA2DS2-VASC-HSF score promote atherosclerosis and are associated with severity of CAD [1] . Aim: To investigate the association of CHA2DS2-VASc-HSF score with severity of Coronary Artery Disease as assessed by Syntax Score (SxS) in patients with Non ST Segment Elevation Myocardial Infarction. Subjects and methods: A total of 50 patients with NSTEMI (37 males and 13 females, their age ranged from 35 to 77 years old with a mean age of 57.8 years old) who underwent coronary angiography were included in our study. The patients were divided into 2 groups according to SxS score (SxS ≤22 and SxS < 22(. Results: This study showed a statistically significant positive correlation between CHA2DS2-VASC-HSF score and Syntax score I of patients. There is a statistically significant positive correlation between CHA2DS2-VASC-HSF score and serum cholesterol levels of patients. A statistically significant positive correlation was found between CHA2DS2-VASC-HSF score and serum LDL levels of patients. Our study also showed a statistically significant negative correlation between CHA2DS2-VASC-HSF score and ejection fraction (EF%) of patients. Conclusions: A newly defined CHA2DS2-VASC-HSF score predicts the severity of atherosclerosis in patients with NSTEMI.

Background:The aim of the present study is to correlate QRS dispersion with the severity of coronary artery lesion in patients with NSTEMI detected by GENSINI score (short term outcome). Methods: The whole study group consisted of 96 (63 males and 33 females) patients presented with NSTEMI . Age ranged from 46 and 75 years with a mean of 57.4 ± 6.8. Table ( 7) summarizes baseline clinical and laboratory data of the study population. Results: We included 96 consecutive patients who were admitted to our Cardiology Care Unit for NSTEMI in the period between Marsh to September 2018. All patients were given the necessary information about the study. Zagazig University, Faculty of Medicine ethics committee approved our study, and a written informed consent was obtained from patients (patients included 63 males and 33 females patients with their age ranged from 46 and 75 years with a mean of 57.4 ± 6.8) . Conclusion: In the current study, we found highly significant positive correlation between admission heart rate and maximum highsensitive troponin T level and Gensini score > 20 in the setting of NSTEMI. A significant positive correlation between age, male gender, QRS measurements, QTc dispersion, LVESD and Grace score and Gensini score > 20 was found in the setting of NSTEMI. A significant negative correlation between LVEF and Gensini score > 20 was found.

Global health is under danger due to COVID-19's overwhelming global spread. Despite the fact that the respiratory system is the primary organ affected by SARS-CoV-2, there is mounting evidence that it can also impact the cardiovascular system. A useful tool for assessing cardiovascular disease is echocardiography. It is affordable, broadly accessible, and offers data that can affect management. Leading international societies advice using only echocardiography when a potential clinical benefit exists, favoring focused assessments, and employing smaller portable equipment due to the danger of staff infection and equipment contamination during the procedure. Several investigations over the past few several different types of echocardiographic anomalies have been described for months in COVID-19 individuals. These findings are summarized in this review, which also discusses potential contributing mechanisms.

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Background More than 40% of patients with non-ST Elevation Myocardial Infarction (NSTEMI) have multi-vessel disease with the rate of in-hospital emergent bypass surgery ranging from 11–13%. So, rapid scoring is critical for optimum management even before P2Y12 loading. Purpose We aimed to determine the role of QRS dispersion at emergency department, as a simple and rapid sign, in predicting coronary anatomy complexity and in-hospital outcome. Methods 192 (126 males, age 57.4±6.8 years) patients with NSTEMI and QRS duration <120 ms who underwent coronary angiography were included. QRS dispersion was automatically measured. Results Using Spearman's rank correlation, SYNTAX score was found to be positively correlated with admission HR (r 0.54, p value <0.001), maximum HsTnT level (r 0.523, p value <0.001), age (r 0.262, p value 0.015), male gender (r 0.286, p value 0.005), QRS dispersion (r 0.248, p value 0.015), QTc dispersion (r 0.289, p value 0.01), and Grace score (r 0.247, p value 0.015). ROC curve analyses for prediction of SYNTAX score >33 were done for variables with significant correlation. By multivariate logistic regression, male gender (OR 5.042, 95% CI 1.633 –15.567, p value 0.005), admission HR >80 bpm (OR 1.088, 95% CI 1.024 –1.157, p value 0.017) and QRS dispersion >20ms (OR 1.020, 95% CI 1.003 –1.037, p value 0.02) were independent predictors of SYNTAX score >33 (table). Patients with QRS dispersion >20 ms had in-hospital higher Killip class (P<0.001), recurrent ischemia (P 0.003), serious ventricular arrhythmias (P 0.01) and higher GRACE score (P<0.001). Binary logistic regression for prediction of SYNTAX score >33 Variables Univariate analysis Multivariate analysis OR (95% CI) P value OR (95% CI) P value Age >61 (years) 1.337 (1.019–4.392) 0.015 0.953 (0.878–1.033) 0.242 Male gender 4.851 (2.014–5.301) 0.001 5.042 (1.633–15.567) 0.005 HR >80 (bpm) 3.945 (1.706–6.953) 0.002 1.088 (1.024–1.157) 0.017 QRS dispersion >20 (ms) 2.911 (0.617–13.738) 0.013 1.020 (1.003–1.037) 0.02 QTc dispersion >53 (ms) 6.101 (1.926–19.323) 0.002 2.378 (1.890–2.561) 0.043 Maximum HsTnT >1105 (ng/L) 3.837 (0.236–8.965) 0.004 2.785 (2.501–3.012) 0.034 Grace Score >112 (points) 7.122 (0.632–12.216) <0.001 2.912 (2.703–3.309) 0.030 Conclusion In NSTEMI, QRS dispersion was positively correlated with SYNTAX score and a cut-off value of 20 ms independently predicted SYNTAX score >33. Regarding in-hospital outcome, QRS dispersion >20 ms was associated with in-hospital higher Killip class, recurrent ischemia, serious ventricular arrhythmias and higher GRACE score