ObjectivesTo assess the efficacy and safety of fluocinolone acetonide 0.025% otic solution versus placebo in treating patients with otic eczema.MethodsIn this multicentre, randomized, double-blind, parallel-group phase 3 clinical trial, conducted at 12 Spanish centres between March 2012 and March 2013, patients received fluocinolone acetonide 0.025% or placebo otic solution twice daily for 7 days (days 1–7) with an 8-day follow-up (days 9–15). Outcome measures included change in itching from baseline (day 1) to study days 4–8 and 9–15, and change in otoscopic signs (erythema, oedema, and scaling) from baseline to the end of treatment (day 8) and end of follow-up (day 15).ResultsPatients treated with fluocinolone acetonide 0.025% (n = 66), as compared with placebo-treated patients (n = 69), showed significantly higher reductions in itching from baseline to study days 4–8 and 9–15, and in individual and global otoscopic signs from baseline to the end of treatment (day 8) and end of follow-up (day 15). Incidence and severity of adverse events was similar between the fluocinolone and placebo groups.ConclusionsFluocinolone acetonide 0.025% otic solution, administered twice daily for 7 days, is an effective and safe treatment for otic eczema.

This work aims to study the influence of carbon fibers addition in physical-chemical properties of bicomponent epoxy resin, produced by POLIPOX, in a composite obtained by RTM. Thermal analyses (DSC (Differential Scannig Calorimetry), TGA (Thermal Gravimetric Analysis) and DMA (Dynamic-mechanical Analysis) were performed in order to compare the results and observe the reinforcement influence on the resin properties. Increased glass transition values and degradation temperatures show that fibers cause a reduction in the molecular motion of polymer chains.