Aim: To compare the efficacy of casein phosphopeptide-amorphous calcium phosphate-fluoride (CPP-ACP-F) paste and 0.2% sodium fluoride mouthwash in the prevention of dental erosion using profilometer. Materials and methods: The buccal surfaces of 36 premolar sound teeth were ground and polished to achieve a flat surface with silicone disks. Samples were allocated in three groups randomly. Group I was pretreated for 5 days four times a day with CPP-ACP-F paste. Group II was pretreated for 5 days with 0.2% sodium fluoride mouthwash four times a day. Group III remained as the control group without any pretreatment. In the next step, all the samples were exposed four times a day for 3 days to carbonated beverages. The samples were rinsed with saline after each erosive cycle and stored in artificial saliva. The profilometer was used to determine the surface loss. The data collected were evaluated using one-way analysis of variance (ANOVA) along with post hoc test. Results: The erosion of group I (CPP-ACP-F paste) and group II (0.2% sodium fluoride mouthwash) was significantly less than that of group III (control group). The erosion in group II was significantly lower than in group I. Conclusion: Both sodium fluoride mouthwash and CPP-ACP-F paste are effective in the prevention of dental erosion. Sodium fluoride mouthwash shows higher reduction in dental erosion when compared with CPP-ACP-F paste. Clinical significance: This study contributes to the understanding of the efficacy of CPP-ACP-F paste and 0.2% sodium fluoride mouthwash in the prevention of dental erosion.