Objective: To determine the value of fetal fibronectin (FFN), cervical length (CL) measurement and their combination as binary predictors for preterm birth (PB) in women with preterm labour (PTL) between 24 + 0 and 34 + 0 weeks. Methods: One hundred fifty-nine patients with signs of PTL (singleton pregnancies (SP) = 125, twin pregnancies (TP) = 34) were evaluated in a retrospective study. Inclusion criteria were contractions > 4/20 min, intact membranes, no bleeding. The cut-off was ≥50 ng/ml for FFN and ≤20 mm for CL measured by transvaginal ultrasound. The primary outcome variable was delivery within 7 days from admission. Results: We evaluated 125 SPs and 34 TPs. In SPs, both methods had a sensitivity of 80%; the specificity was 82% for FFN, and 50% for CL. For the combination of both tests sensitivity was 80% and specificity 88%. In TPs, the sensitivity of both tests was lower (FFN 33%, CL 67%) but the combination of both tests represented the highest result for specificity (77% compared to 68% for FFN alone and 32% for CL alone). Conclusion: The combination of FFN and CL in PTL results in a significant higher specificity in SPs. In TPs the performance of the tests is less accurate.

Gestational diabetes is one of the most serious pregnancy associated disorders affecting up to 14% of all pregnant women. The increasing incidence also seen in Switzerland, has been due, among other factors, to the rise of maternal age and maternal body mass index. Due to its high incidence, its major impact on pregnancy outcome and the therpeutic approaches, an universal, instead of a selective screening is preferred. The clinical relevant key points are discussed in this review.

Eine 18-jährige Patientin stellt sich in der Poliklinik wegen eines seit Längerem bestehenden vaginalen Ausflusses vor, der wenig fötid und sehr wässrig ist. Kein Juckreiz, kein Brennen. Der Ausfluss habe vor einigen Wochen begonnen und nun zugenommen. Die Sexualanamese ist unauffällig, die Patientin hat aktuell keinen Partner.