Background: An outbreak of COVID-19 caused by 2019 novel coronavirus started first in Wuhan, Hubei province of China. Thereafter it spreaded to different countries of the world. Cases among children has been increasing day by day. Despite taking all measures of prevention virus spreading is uncontrolled. Objectives: To determine the clinical features and laboratory profile of children with COVID-19. Methods: This was a cross sectional study conducted in Dr. MR Khan Shishu Hospital and Institute of Child Health, Dhaka. Clinical and laboratory profile were analyzed among the children (aged 0-16 years) admitted between 1st May 2020 to November 2020 with positive RT-PCR for COVID-19. Data were analyzed by using SPSS. Results: Total 159 cases were included in the study. The most common symptom was fever (97.5%), then the second most common was cough (80.5%), other symptoms were diarrhea (28.3%), vomiting (17%), anorexia (30.8%) and weakness (30.2%). WBC count was within normal limit, leucocytosis was found in 5% cases and leucopenia in 3% cases. Few cases were reported with neutropenia and lymphopenia. Few cases were reported as thrombocytosis. ESR and CRP were high. Chest X-ray showed opacities in 62.9% cases. In most of the cases it was bilateral, few cases showed unilateral. In 37.1% cases it was normal. The disease category of all infected children remained same all through the hospital stay and no mortality was seen. Conclusion: Children with COVID-19 had distinct clinical features. Fever and cough were the most common symptoms. WBC count was found within normal limit but ESR and CRP were high. Chest radiograph showed opacities in majority cases. The outcome of COVID-19 in children was good. DS (Child) H J 2020; 36(2): 95-100

Background: Dengue fever has become one of the most important public health concerns now a day due to increasing complications and fatal outcomes. Dengue hemorrhagic fever and dengue shock syndrome are life threatening but reversible complications of dengue fever. Objectives: This study was performed to evaluate the relationship between platelet count and hematocrit with the severity of dengue infection in pediatric age group. Materials & Methods: This was a prospective observational study which included 280 dengue seropositive children of 1 month to 15 years, conducted during 1st June to 30th November, 2018 in a tertiary care hospital of Dhaka. Results: Out of 280 dengue cases, 187(66.78%) had thrombocytopenia and 88(47%) had raised hematocrit. Among the thrombocytopenic patients 44% had dengue fever, 47% had dengue hemorrhagic fever and 9% dengue shock syndrome. A significant co-relation was observed between the severities of thrombocytopenia and raised hematocrit with the appearance of dengue warning signs in case of dengue hemorrhagic fever. Conclusion: Thrombocytopenia and raised hematocrit were related to the severity of dengue hemorrhagic fever. Bangladesh J Child Health 2020; VOL 44 (2) :74-77

Background: Dengue fever is a major public health problem in Bangladesh. Suspicion, attention, and early tests are necessary to identify concurrent illnesses with dengue. This study was assessed to find out the other infections associated with Dengue fever to minimize morbidity and mortality. Materials & Methods: Hospitalized patients with fever were initially selected. After clinical and laboratory evaluation, fever with dengue NS1 or IgM positive cases were included. Among the 175 dengue patients; during follow-up, some patients had a persistent high fever, cough, dysuria, appearance/deepening of jaundice,and other toxic features that could not correlate with dengue. Relevant investigations were done to find out the co-infections among them. Results: Co-infection was found in 13.1% cases, among 5to 13 years of age group with female predominance. Dengue NS1 was found positive in 39.1% and IgM positive in 60.9% of cases. Typhoid fever 39.1%, paratyphoid fever 4.3%, rickettsial fever 13%, HAV infection 26%, HEV infection 8.7%, UTI 4.3%, and bacterial pneumonia 4.3% were found among the cases of dengue fever as co-infection. Conclusion: The study shows that dengue patients are at a higher risk of having other infections. Thirteen percent of the dengue patients were found associated with different co-infection. Bangladesh J Child Health 2020; VOL 44 (3) :157-160

Abstract:Background: Enteric fever is endemic in Bangladesh. This is an important cause of morbidity and mortality in developing countries. The aim of the study was to evaluate the clinical and laboratory profiles, culture positivity rate and sensitivity pattern of Salmonella enterica.Methodology: This was an observational study carried out in a tertiary care hospital in Dhaka, Bangladesh during the period from January to December, 2017. Total 120 children who had enteric fever diagnosed either by positive blood culture or widal test with significant titre for Salmonella Typhi or Paratyphi were enrolled in the study.Results: Fever and abdominal pain were the main presenting symptoms. Leucocyte and platelet count were normal whereas ALT and CRP found to be elevated. Culture positivity rate in our study was 43.33%. Of the culture positive isolates, 88.46% were Salmonella Typhi and 11.53% were Salmonella Paratyphi. All the isolates were sensitive to third and fourth generation cephalosporins while 79.54% showed intermediate sensitivity to ciprofloxacin. Conclusion:A good sensitivity to third and fourth generation cephalosporins against Salmonella was noted whereas ciprofloxacin found to be less sensitive. Ceftriaxone showed remarkable efficacy when used as monotherapy.

Aim: This study was aimed to find out the mismanagement of infantile masturbation and the outcome of the cases who were treated with anti-epileptic drugs. Study Design: Retrospective. Place and Duration of Study: This study was conducted at outpatient department of Rehabilitation and Neurology unit of Dr. M R Khan Shishu Hospital and Institute of Child Health, Dhaka Bangladesh, between 2013-2022. Methods: Data were collected from records which included socio-demographic data and clinical features of masturbation in children. Data related to treatment was also collected and their outcome was observed. Results: Among 50 patients, majority (74%) had age of onset between 12-36 months of age.   Mean age was 43±26 months, the range was between 4 months to 84 months. Female were predominant (60%). Most of the children came from urban area (86%) and belong to nuclear family (78%). They presented with stereotype movement of variable duration and there was no alteration of consciousness. Prone positioning was more frequent than prone to supine position (78% Vs 18%). There was no laboratory and EEG abnormalities among the cases. Thirty two percent patients were treated with anti-epileptic drugs from outside and among them 2 (12%) was given sodium valproate and rest 14 (88%) were treated with phenobarbitone. But there was no clinical improvement in these cases. Conclusion: Use of anti-epileptic drugs was not associated with any clinical improvement in children with infantile masturbation.