Polyhedral oligomeric silsesquioxane (POSS)/poly(ethylene glycol) diacrylate (PEGDA) biodegradable nanohybrids were synthesized in which modified POSS was chemically incorporated into the polymer chain as reinforcing nanoparticles during a blue light photocuring process. First, POSS diacrylate (POSSA) was prepared by the simple reaction of POSS with acryloyl chloride and the product obtained was identified by Fourier transform infrared spectroscopy and 13 C NMR. Second, POSSA was incorporated into the PEGDA matrix in various concentrations in the presence as well as the absence of a reactive diluent. Finally, some characterizations such as XRD, TEM, equilibrium swelling, viscoelastic behavior, mechanical properties and cytocompatibility tests were performed to evaluate the effectiveness of these nanoparticles within the PEGDA polymer matrix. The results revealed that POSSA acted as a crosslinking agent as well as an inorganic nanofiller to enhance the properties of PEGDA and also that the most effective content of these nanoparticles should be optimized in the range 1.5-3 wt%. This study suggests acrylated POSS as an effective nanoparticle to promote the efficiency of photocured nanohybrids used in medical applications.