Purpose: cancer is chronic disease that can create numerous health problems. The utility of novel approaches such as telenursing can help patient with cancer. This study aimed to assess systematic review the effect of telenursing on care of patients with cancer.Methods: we searched electronic database from inception up to February 7 2022. The database include science direct, PubMed, Scopus, and Cochran database. In this study, the search process includes combination of keywords based on MeSH terms. All of articles with sevsral terms in title ″telenursing″, ″tele­_nursing″, ″cancer″, ″neoplasm″, ″tumor″, and ″malignancy″was included.Results: our initial search yielded 412 recorded, 8 studies were included. The data collected during time of study, recommends that telenursing improve supportive care needs of patients with cancer, quality of care, and patient satisfactory. Also, it decrease cancer complication as fatigue, nausea, depression, anxiety, pain, and feeling of well-being and reduce cost related cancer. Conclusion: although, most studies demonstrate that telenursing in cancer care is effective, a big challenge in this study was methodological heterogeneity and various instruments tool that influence correct assessment telenursing on cancer care. telenursing is as a new model in current century. The use of technology can help removal of long distance and cost restriction.