We propose a new generation of reprogrammable multi-functional bias encoded metasurfaces for dynamic wave manipulation using liquid crystals (LC). This metadevice is an array of unit-cells based on LCs to provide the desired phase steps based on its large birefringence property. The presented 3-bit coding metasurface (CM) use 8 states of "000"-"111" to control and manipulate the scattered wave at λ=1.4µm for several applications. The metasurface is introduced in detail and followed by several examples to show its versatility. Steered pencil, regular, and focused vortex beams with different topological charges are realized. The theoretical predictions are confirmed by numerical simulations. The proposed CM enables the realization of multifunctional optical wavefront manipulation and future intelligent optical devices.

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Colistin relates to the polymyxin group of antibiotics. This antibiotic is still used to destroy gram-negative bacteria as a last resort. However, resistance to this antibiotic has been reported and is appearing day by day. Not much information is available on the exact mechanisms of resistance to this antibiotic. Also, not enough information about pharmacokinetics and pharmacodynamics is available, so the optimal dose should be determined to use these antibiotics to prevent the toxic effects of this antibiotic. In current study, additionally to their pharmacokinetics and pharmacodynamics, we have presented current knowledge about the genes and two-component systems that may cause such resistance to polymyxin and colistin.

This work presents two approaches to design and implement three-dimensional (3D) graded index (GRIN) flat lenses consisting of concentric annular segments. Generally, the design of GRIN flat lenses calls for segments with very specific tailored permittivity which makes the realization of the lens challenging. To meet this challenge, each segment of the lens is replaced with a three-layer structure consisting of two materials with a high and a low dielectric constant in such a way that the high permittivity layer is sandwiched between two low permittivity layers. By treating the lens segments as transmission lines and taking the effect of multiple reflections into account, the layer thicknesses are adjusted in such a way that the rays passing through different segments interfere constructively at a focal point. To further improve the focusing performance, a practical design approach is introduced in which each segment of the lens is made of a symmetric seven-layer structure using only two materials (alternating in arrangement) with a high and a low dielectric constant. This design provides the following features: (1) almost all of the incident power passes the lens without considerable reflection, (2) the lens provides a constructive interference of the incident wave at a focal point, and (3) the lens has the potential to be manufactured using available material and technology. Numerical examples are provided in which silica and silicon are utilized as low and high permittivity materials, respectively.