No abstract

degenerative patterns of the arterial system of the lower extremities have been studied in an age series. The intensity of these alterations has been correlated with the distribution of the atheromatous plaques and thrombosis as well as with the effective tension at various levels as calculated by Burton's formula. Evidence is presented for the concept that the lipids in atheromatous plaques arise as a product of these degenerative reactions within the vessel wall, rather than by diffusion from the circulation through the endothelial barrier.IN PREVIOUS reports we have defined aging processes in blood vessels as those alterations resulting from the effects of wear and tear factors which have been operating over a relatively long period of time.1-6 Specifically, these investigations have dealt with the comparative rates of degeneration, new formation and subsequent calcification of the elastic elements of arteries in various anatomic sites. In general, intimal plaques were observed to occur most frequently in those arteries in which these alterations were most marked along the internal elastic zone, and it was further pointed out that physical factors play an important role in the point of localization and rate of development of these plaques. Thus, the lower portion of the aorta and the coronary arteries show a relatively rapid development of aging processes and a high rate of occurrence of intimal plaques, while the hepatic and pulmonary arteries show atheromata rarely and only a slow and mild progression of elastic tissue calcification. Differences in the rate of development of these changes in elastic elements between Negro and white groups have been studied in comparable segments of coronary, renal, splenic and pulmonary arteries, as well as various portions of the aorta.From the

No abstract

Seven cases of quadrilateral chronic occlusive arterial disease different from other known chronic occlusive arterial diseases as evidenced by arteriography, pathology, and clinical manifestations are reported. They resemble some of the cases originally described by Buerger.

No abstract