Objective To ascertain patients' views on the benefits of and possible memory loss from electroconvulsive therapy. Design Descriptive systematic review.
Maximum likelihood equations for the estimation of Gumbel distribution parameters from censored samples are derived; expressions for their large‐sample standard errors are also given. Censored samples arising in annual maximum flood series are described, and it is shown that a set of historic floodmarks may, under certain assumptions, be combined with recent noncensored data, to form what is essentially a censored sample. Maximum likelihood methods are applied to such a sample, and the resulting estimates are compared with those obtained from the recent data alone. The estimates agree closely, and the use of the extra information contained in the historic floodmarks is shown to lead to a reduction in the large‐sample standard errors of the estimates.
Treatment with an SSRI plus supportive care is more effective than supportive care alone for patients with mild to moderate depression, at least for those with symptoms persisting for 8 weeks and an HRDS score of > or = 12. The additional benefit is relatively small, and may be at least in part a placebo effect, but is probably cost-effective at the level used by the National Institute for Health and Clinical Excellence to make judgements about recommending treatments within the National Health Service. However, further research is required.
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