With the close of 2020 unprecedented year, a year like no other, Nigerians is still reeling from the impacts of an emerging, rapidly and evolving COVID-19 pandemic, while the spring continue to unfolded. COVID-19 was considered a “deaths of despair” with an opioid crisis and realizing that humanity is in for a long haul with COVID-19, itself may be a game changer. If we expected COVID-19 to be short lived, we have been remarkably, if not catastrophically, disappointed. As many people were already feeling significantly stressed, and where depression was increasing risks of overdoses and suicide. From time immemorial, humankind have suffered the psychological effects of various catastrophes, such as wars, floods, famines, wildfires, earthquakes, windstorms and last but certainly not least, the possibility of outbreaks of potentially deadly infectious diseases. Hence, these zoonosis diseases, result from pathogens being transmitted from animals to humans. To protect ourselves from zoonoses, there is need for new measures and precautions, for instance ending and preventing deforestation as well as protecting conservation areas and endangered species against such danger. Of course, we are certainly no exception today as people try to figure out how to cope and help others cope with the grief, stress, and anxiety caused by the greatest health challenge of our time: the coronavirus 2019 (COVID-19) pandemic. With more than 1,129 Nigerian having lost their lives as of October 24, 2020 and more than 61,882 thousand infected since COVID-19 first gripped our nation, although reports suggest that the incidence of COVID-19 has begun to drop, the pandemic has taken a profound psychological and emotional toll on us all. However, social and behavioral scientists have identified some strategies to help us face our fears, as well as even rise to the challenge of supporting others during this fraught time. While awaiting the unprecedented investment in the development of the SARS-CoV-2 vaccine and the simultaneous scale up of vaccine manufacturing which has been taking place, including unprecedented collaboration and resources to develop safe and effective vaccines for COVID-19 that can be manufactured and delivered in the scale of billions of doses to people around the globe. Continuing in this unprecedented commitment towards collaboration as well as transparency is essential towards ensuring that effective and reliable access to information will continue to inform policy decisions at all levels to support the development of national roadmaps to accelerate as well as sustain progress towards public health interventions and building trust in communities that will benefit from a safe and effective vaccine as well as making sure we get it to them as quick as possible.