Data equipped with this article were collected from Northern Bay of Bengal (NBoB) wrapping both the eastern and western coast for CTD and sediment samples and only the eastern coast for water sampling. In-situ data of physical parameters, heavy metals, elements, Total Organic Carbon (TOC), nutrients, chlorophyll-a and phaeopigment were sampled across the shallow continental shelf. These data were assembled from 15 CTD points, 76 water samples, and 10 surface sediment samples adjacent to Bangladesh coast. Vertical CTD profiles were collected for Temperature ( °C), Salinity (PSU), Density (kg
m
−3
), Turbidity (NTU), Fluorescence (mg
m
−3
), and Dissolved Oxygen (DO, mg/l). Heavy metals (mg/l) of water column enlisted as Calcium (Ca), Cadmium (Cd), Copper (Cu), Cobalt (Co), Iron (Fe), Manganese (Mn), Magnesium (Mg), Nickel (Ni), Lead (Pb), and Zinc (Zn). Total Organic Carbon (TOC) was measured as Non-Purgeable Organic Carbon (NPOC) in ppm. Measurements of Chlorophyll - a, Nitrate, Nitrite, Phosphate, Ammonia, Silica and Phaeopigment were taken from 76 water sampling points. The survey was conducted with the assistance of a fishing vessel ‘Agro food-4 ‘of ‘Sea Resource Ltd.’ lengthening a fishing period from January to February (in winter), 2016. SBE 19 plus V2 CTD machine was deployed for sampling of vertical physical features, Niskin sampler of HYDRO-BIOS consisting of a non-metallic interior was used to collect water sample. Sediment was collected by Van Veen Grab sampler with built-in messenger. Water samples were analyzed following the standard procedure in the laboratory to access in-situ data. The shallow coastal and offshore regions of Bangladesh support for vast biological resources to its adjacent inhabitants. Therefore, understanding the influence of physico-chemical properties on other biological resources in coastal ecosystem is a crucial one to investigate. However, the shelf region of the BoB has a lack of in-situ baseline or reference data to compare with in terms of ocean biogeochemistry. Thus, these datasets can be utilized for further reference and also in validating other remotely-sensed physico-chemical parameters in this region.