No abstract

Congenital arteriovenous malformations (AVM) of the pelvic organs are uncommon. They have been reported under different names such as cirsoid aneurysm, arteriovenous fistula, and arteriovenous malformation. Several cases of cirsoid aneurysm of the uterus have been reported in the l i t e r a t~r e l -~ in women of childbearing age who had had multiple childbirth, or an abnormal menstrual or obstetric history. Nulliparous women with AVM are very rare (only two nulliparous women in a review of the l i t e r a t~r e .~.~) .In rare cases pelvic AVM may occur in males.8-'0 The oldest patient in which this condition has occurred is a 63-yr-old female." We report an unusual case of a 72-yr-old woman presenting for the first time with postmenopausal bleeding in whom clinical examination steered the workup to ultrasonic evaluation which provided the diagnosis by real-time ultrasound study. CASE REPORTA 72-yr-old retired female nurse gravida 0, para 0, widowed for 7 yr, was referred to the gynecological oncology service for excruciating cramps in the lower abdomen and vaginal bleeding of recent onset. A curettage had failed due to hemorrhage from accidental laceration of anterior vaginal wall. She had had a cardiac murmur since 1927 (when she was 19 yr old) and bilateral vein stripping for varicose veins was carried out in 1950 at age 41. Age at menarche was 14 yr. Ultrasound examination showed numerous cystic lesions in the pelvis (Fig. 11, some of which were noted in the uterus (Fig. 2) while others were present in the adnexa, probably involving the ovaries. Some of these lesions were observed to show a slight change in size during the realtime study. There were a few tortuous veins which appeared to be of greater than normal caliber. The right iliac artery exhibited a bounding pulse. These findings were felt to be highly suggestive of an arteriovenous malformation of the uterus with extension into the pelvis. A highly vascular lesion with cystic changes such as a leiomyosarcoma could not be entirely excluded, but in the absence of any solid components and the presence of pelvic and adnexal extension, this was considered unlikely. Angiographic examination showed a large arteriovenous malformation in the pelvis supplied by branches from both internal iliac arteries ( Fig. 3) with large tortuous draining veins (Fig. 4). There was no evidence of any tumor. At surgery, the uterus was soft and larger than expected for the patient's age. Large dilated vessels were seen in the right utero pelvic ligament. The right round ligament was extremely dilated and deformed with large vessels. Ligation of all identifiable feeding blood vessels, partial resection of the AVM, bilateral salpingo- 295

The ototoxicity associated with long‐term cisplatin therapy in gynecologic cancer patients was investigated. Twenty‐three of 31 patients developed hearing loss and 21 patients reported the onset of tinnitus. The hearing loss was bilateral, cochlear, and permanent. The tinnitus was transient and not predictive of change in hearing level. The likelihood of developing hearing loss appeared to be greatest in patients older than 40 years and in patients with preexisting hearing loss. The amount of change did not appear to be related to the degree of preexisting hearing loss.