No abstract

Deep learning based approaches have been dominating the face recognition field due to the significant performance improvement they have provided on the challenging wild datasets. These approaches have been extensively tested on such unconstrained datasets, on the Labeled Faces in the Wild and YouTube Faces, to name a few. However, their capability to handle individual appearance variations caused by factors such as head pose, illumination, occlusion, and misalignment has not been thoroughly assessed till now. In this paper, we present a comprehensive study to evaluate the performance of deep learning based face representation under several conditions including the varying head pose angles, upper and lower face occlusion, changing illumination of different strengths, and misalignment due to erroneous facial feature localization. Two successful and publicly available deep learning models, namely VGG-Face and Lightened CNN have been utilized to extract face representations. The obtained results show that although deep learning provides a powerful representation for face recognition, it can still benefit from preprocessing, for example, for pose and illumination normalization in order to achieve better performance under various conditions. Particularly, if these variations are not included in the dataset used to train the deep learning model, the role of preprocessing becomes more crucial. Experimental results also show that deep learning based representation is robust to misalignment and can tolerate facial feature localization errors up to 10% of the interocular distance.

Patients with severe COVID-19 have overwhelmed healthcare systems worldwide. We hypothesized that machine learning (ML) models could be used to predict risks at different stages of management and thereby provide insights into drivers and prognostic markers of disease progression and death. From a cohort of approx. 2.6 million citizens in Denmark, SARS-CoV-2 PCR tests were performed on subjects suspected for COVID-19 disease; 3944 cases had at least one positive test and were subjected to further analysis. SARS-CoV-2 positive cases from the United Kingdom Biobank was used for external validation. The ML models predicted the risk of death (Receiver Operation Characteristics—Area Under the Curve, ROC-AUC) of 0.906 at diagnosis, 0.818, at hospital admission and 0.721 at Intensive Care Unit (ICU) admission. Similar metrics were achieved for predicted risks of hospital and ICU admission and use of mechanical ventilation. Common risk factors, included age, body mass index and hypertension, although the top risk features shifted towards markers of shock and organ dysfunction in ICU patients. The external validation indicated fair predictive performance for mortality prediction, but suboptimal performance for predicting ICU admission. ML may be used to identify drivers of progression to more severe disease and for prognostication patients in patients with COVID-19. We provide access to an online risk calculator based on these findings.

Disease progression modeling (DPM) using longitudinal data is a challenging machine learning task. Existing DPM algorithms neglect temporal dependencies among measurements, make parametric assumptions about biomarker trajectories, do not model multiple biomarkers jointly, and need an alignment of subjects' trajectories. In this paper, recurrent neural networks (RNNs) are utilized to address these issues. However, in many cases, longitudinal cohorts contain incomplete data, which hinders the application of standard RNNs and requires a pre-processing step such as imputation of the missing values. Instead, we propose a generalized training rule for the most widely used RNN architecture, long short-term memory (LSTM) networks, that can handle both missing predictor and target values. The proposed LSTM algorithm is applied to model the progression of Alzheimer's disease (AD) using six volumetric magnetic resonance imaging (MRI) biomarkers, i.e., volumes of ventricles, hippocampus, whole brain, fusiform, middle temporal gyrus, and entorhinal cortex, and it is compared to standard LSTM networks with data imputation and a parametric, regression-based DPM method. The results show that the proposed algorithm achieves a significantly lower mean absolute error (MAE) than the alternatives with p < 0.05 using Wilcoxon signed rank test in predicting values of almost all of the MRI biomarkers. Moreover, a linear discriminant analysis (LDA) classifier applied to the predicted biomarker values produces a significantly larger area under the receiver operating characteristic curve (AUC) of 0.90 vs. at most 0.84 with p < 0.001 using McNemar's test for clinical diagnosis of AD. Inspection of MAE curves as a function of the amount of missing data reveals that the proposed LSTM algorithm achieves the best performance up until more than 74% missing values. Finally, it is illustrated how the method can successfully be applied to data with varying time intervals. This paper shows that built-in handling of missing values in training an LSTM network benefits the application of RNNs in neurodegenerative disease progression modeling in longitudinal cohorts.

Abstract. Automatic visual speech recognition is an interesting problem in pattern recognition especially when audio data is noisy or not readily available. It is also a very challenging task mainly because of the lower amount of information in the visual articulations compared to the audible utterance. In this work, principle component analysis is applied to the image patches -extracted from the video data -to learn the weights of a two-stage convolutional network. Block histograms are then extracted as the unsupervised learning features. These features are employed to learn a recurrent neural network with a set of long short-term memory cells to obtain spatiotemporal features. Finally, the obtained features are used in a tandem GMM-HMM system for speech recognition. Our results show that the proposed method has outperformed the baseline techniques applied to the OuluVS2 audiovisual database for phrase recognition with the frontal view cross-validation and testing sentence correctness reaching 79% and 73%, respectively, as compared to the baseline of 74% on cross-validation.The final publication is available at Springer via http://dx