Introduction: Dental fluorosis is a chronic condition of enamel hypomineralization resulted from excessive ingestion of fluoride during tooth development. Different treatment protocols were used to improve esthetic appearance of fluorosed teeth. Aim: To evaluate patient satisfaction on esthetic improvement of mild to moderate fluorosed teeth after treating with different minimal-invasive treatment modalities. Patients and Methods: Sixteen participants were randomly assigned in 8 treatment protocols with 20 teeth at each protocol (n=20). (P 1 ) Opalescence boost PF 40%. (P 2 ) Opalustre. (P 3 ) MI-Paste Plus. In (P 4 ) teeth were treated with Opalustre + Opalescence boost PF 40%. In (P 5 ) Opalescence boost PF 40% + MI-Paste Plus, while in (P 6 ) Opalustre +MI-Paste Plus. Whereas (P 7 ) Opalustre + Opalescence boost PF 40% + MI-Paste Plus. (P 8 ) control. Patient satisfaction was gauged using a visual analog scale(VAS) at 4 different time points; immediately after application (T 1 ), 14 days later (T 2 ), 3 months later (T 3 ), and 6 months later (T 4 ). Results: All treatment protocols showed significant difference over control group at all evaluation times. Regarding treatment protocol, the highest patient satisfaction was recorded in P 4 and P 7 . The lowest patient satisfaction was recorded in P 3 . Moreover, concerning evaluation time the highest patient satisfaction was recorded at T 3 and the lowest patient satisfaction was recorded at T 1 .The highest patient satisfaction was recorded at 14 days evaluation of P 4 and 6 months evaluation of P 7 . Conclusion: The combined treatment protocol of Opalustre™ and Opalescence™ boost™ PF 40% provided the highest "patient satisfaction» in treating mild to moderate fluorosed teeth regardless of using MI-Paste Plus®. MI-Paste Plus® provides stability of patient satisfaction results at 6 months' follow-up.