We report a two-photon responsive drug delivery system (DDS) namely, p-hydroxyphenacyl-naphthalene-chlorambucil (pHP-Naph-Cbl) having two-photon absorption (TPA) cross-section of ≥ 20 GM in the phototherapeutic window (700 nm). Our DDS exhibited...
A single chromophore based dinitrophenylsulphonyl–naphthalene–chlorambucil conjugate drug delivery system is presented for the dual stimuli controlled release of SO2 and chlorambucil.
Glioma is one of the most perplexing cancers because of its infiltrating nature, molecular signaling, and location in central nervous system. Blood-brain barrier acts as a natural barrier to the glioma making it difficult to access by conventional chemotherapy. Clinicians are using natural compounds or their derivatives for several diseases including different cancers. However, the feasibility of using natural compounds in glioma is not explored in details. Natural compounds can act over a wide variety of signaling pathways such as survival and metabolic pathways and induce cell death.
Some of the natural agents have additional benefits of crossing biological barrierssuch as blood-brain barrier with ease having few or no impact on the surrounding healthy cells. All of these benefits make natural compounds a prospective candidate for the glioma management. This article evaluates the benefits of using natural compounds for glioma therapy and their possible mechanism of actions. We have discussed the natural compounds assessed currently for glioma therapy and proposed a few novel natural compounds with potential antiglioma effect based on their mechanism of action.
We
demonstrated for the first time without any chemical modification
the two-photon absorption (TPA) cross-section can be enhanced and
red-shifted to the near-infrared (NIR) region by the ground-state
proton-transfer (GSPT) process. Using GSPT, we developed a simple
binol-based aggregation-induced emission (AIE)-fluorogenic phototrigger
having a large two-photon uncaging cross-section in the “phototherapeutic
window”. As a proof of concept, we showed our phototrigger
for the release of two different anticancer drugs in the NIR region.
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