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The objective of this paper is to analyze the effects of climate change on maize production in Mali during the period 1990-2020. The unit root test (augmented Dickey-Fuller) was used to check the order of integration between the variables in the study. The ARDL (autoregressive distributed lag) approach to cointegration limits is applied to assess the association between the study variables with evidence of a long-term relationship. The unit root test estimates confirm that all variables are stationary at the combination of I(0) and I(1). The results show that precipitation and temperature in June and July have a negative and highly significant effect on maize production in both the short and long term analyses. Among other determinants, the area of land devoted to maize crops and GDP per capita have a positive effect on production. The estimated coefficient on the error correction term is also highly also highly significant As Mali's population grows, in the coming decades the country will face food security challenges. Possible initiatives are needed to configure the Malian government to address the negative effects of climate change on agriculture and ensure adequate food for the growing population.

Les auteurs rapportent le cas d’une patiente malienne suivie pour cancer du sein métastatique au niveau osseux sous chimiothérapie chez qui le diagnostic de la COVID-19 a été posé 9 jours après le début des troubles digestifs avec survenue du décès de la patiente avant toute prise en charge de cette virose. Face au mauvais pronostic des patients atteints de cancer et de COVID-19, les auteurs insistent auprès des cliniciens sur la nécessité d’une attention particulière devant de telles associations morbides afin de trouver l’équilibre thérapeutique entre ces deux pathologies.

Introduction: Sickle cell disease has an evolution characterized by acute and chronic complications that affect almost all the target organs of the body (bones, eyes, heart, kidneys, brain ...). The purpose of this study was to describe the bone complications of sickle cell disease. Patients and Methods: This was a retrospective study performed in the Hematology-Oncology Department of the Donka Teaching Hospital over a five-year period (5 years) from 1 January 2011 to 31 December 2015. Results: The frequency of bone complication of sickle cell disease was 15%. There was a predominance of the female sex with the sex ratio of 0.8. The average age of the patients was 27.5 years with extremes of 10 and 50 years. The main reason

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