The integration of the ASTER image processing and the airborne spectrometric Gamma-Ray interpretation helped in identifying the types and illustrating the distributions of the probable sites for radioactive mineralization at the Gabal Abu Garadi area. Appling various techniques of image processing for Landsat OLI and ASTER satellite to discrimination the differently exposed rock units and extract major and minor structural lineaments. This study resulted that the ASTER VNIR-SWIR bands are effectively used for clarifying the sericite, kaolinite, chlorite, illite and hematite bearing alteration zones, whereas the ASTER TIR bands are most effective in delineation of the silica-rich zones which could be pathfinders for radioactive mineralization within the study area. The resultant alteration maps show good coincidence with the explored uranium sites and suggest further similar unexplored sites. The predominance of low eTh/eU= 1.31 indicates U mobilization and reveals that magmatic differentiation was not the sole process responsible for the concentration of these radioactive elements in the Abu Gradi area. Where the presence of adequate structures such as shear zones and fault planes facilitates the circulation of hydrothermal fluids and meteoric waters leading to mobilization and a redistribution of uranium. This paper could assist the principals of uranium exploration techniques.